An Introduction to Avemar/Immunovet


I apologize for the length of this article but it is here to answer questions that I receive every day.  It is less time consuming for me to put the information here for you then to constantly repeat the answers!

Because the majority of studies worldwide have been conducted with humans and Avemar, we should look closely at the results of
these studies before I tell you about the results of an ongoing study with dogs and Immunovet

What is Immunovet?

Avemar or Immunovet is derived from the germ (endosperm, or seed) of the wheat plant, and is a by-product of milling of wheat kernels to produce flour. It differs from ordinary wheat germ in that it is fermented to concentrate the substituted benzo-quinones, which are biologically active. Concentration allows the immunomodulatory effects of the substituted benzo-quinones to be obtained without the consumption of impractically large amounts of wheat germ.  The fermented wheat germ product produced is then treated with ionizing energy to reach the appropriate microbiological purity.

The finished product is rich in macro- and microelements, vitamins and unsaturated fatty acids. Its important components include herbal benzoic- and hydroquinones which have immune modulating and antimicrobial effects   Immunovet and Avemar are manufactured in the same technological way during the production of the active substances; the two production lines separate during the solidification or drying steps. Avemar contains mainly the water soluble particles of the biologically active substances, and Immunovet contains the water soluble part AND the solid parts as well.  If we look only at the raw production method, then Immunovet may contain more types of the useful molecules than does Avemar.  This tells us a lot about the ingredients.  The raw materials are mainly identical to Avemar but Immunovet gets some flaked corn during the drying and standardizing process which acts as a carrier. Technically, this makes it a totally different product than Avemar.

How does Immunovet work?

In short, Immunovet helps in immune system defenses. The product has a complex biological effect which affects both the humoral and cellular immune systems.

The mutated genes in cancer cells constantly urge these malignant cells to divide. In order to maintain the processes of rapid cell division, the cell metabolism must also be changed; the cell needs to adapt nucleic acids (RNA/DNA) and other constituents for its own use. Cancer cells adapt their metabolism to gain energy in a way that enables them to utilize the most abundant resource in circulation: glucose. (This is why so many “cancer diets” are based on no carbohydrates and no sugars.). In order to maintain a continuous proliferation, it is crucial that glucose is utilized continuously for synthetic (anabolic) biochemical processes.

Tumor cells easily adapt to this glucose-based metabolism and are capable of taking up and using enormous quantities of this molecule - up to 20-30 times more than normal cells.  One part of glucose is used by cancer cells for energy production, while another part will be used for the synthesis of nucleic acids, which are the building blocks of RNA and DNA.

To make a very complex group of processes simple for us lay people, the way Immunovet works is to decrease the glucose-uptake of tumor cells in a dose-dependent manner and inhibit the production of ribose and deoxyribose, a sugar that is the backbone of DNA.  It also inhibits key enzymes that cancer cells need to grow.  Further, Immunovet enhances TNFalpha (tumor necrosis factor alpha) production, thereby inhibiting tumor angiogenesis.  Angiogenesis is the ability of cancer cells to keep itself well supplied with blood.  It produces an enzyme that tells the circulatory system to send up more circulation or blood supply.  A lot of research in the States has been focused on anti-angiogenesis but Immunovet works on many fronts which makes it a more powerful weapon. Think of cancer as an evil entity that circumvents the natural processes in the body to establish an evil empire which builds itself into a monster!  Immunovet deconstructs cancer cells by working in many of these processes, turning them back into what they were before the onslaught of cancer which took control and cleverly used these natural processes to grow itself at an enormous rate.  

Immunovet also has an immune modulating effect by exerting a selective inhibition of MHC-I (major histo-compatibility-I) expression on the surface of tumor cells. Immunovet seems to restore the immune system to its pre-damaged condition. The MHC genes are responsible for regulating antibody recognition which means Immunovet is useful in autoimmune diseases, as well.

There have been hundreds of clinical studies with Avemar throughout the world and more recently, in the United States. Many of these studies showed that Avemar induces apoptosis or programmed cell death of cancer cells after the first 24 hours of use. It also has significant anti-inflammatory effects and supports detoxification, aiding the body in disposing of the dead cancer cells and any toxins formed in the process of apoptosis. For breast cancer, Avemar blocks the estrogen that stimulates the growth of these cells.  All in all, Avemar is an increasingly important alternative treatment.   Results of cell studies, animal studies, and human clinical trials focused on cancer show that Avemar has exhibited significant anti-cancer effects in a broad variety of cancer types and also positive effects in auto-immune diseases (For More information on the studies of Avemar for humans, click here to visit “Human Clinical Trials with Avemar).

How is it used?

Immunovet’ immune-modulating ability makes it very useful for many treatments.  We are still discovering how it works on various body systems but so far, it is used to assist in the treatment of…

Immune and autoimmune diseases.

  Benign and malignant tumors

●  Skin diseases by increasing the efficiency of the therapy of various
    infectious skin diseases.
  Allergic skin inflammation and increased wound healing by helping to stop
    the licking of itchy skin.

  Painful arthritis.

 Overall improvement of the physical condition, and quality of life.

 Treatment of physically rundown animals.

  Aiding in the recovery after surgical operations.
  Reduces the harm done by stress.

Side Effects

The only known side effects can be a soft stool but that is seen infrequently.  No other known other side effects have been noted.

Known Interactions

It is used in conjunction with all forms of chemotherapy and has been proven to extend survival time and quality of life in human patients without any side effects except a loose stool.  It should not be taken at the same time as vitamin C (allow a 2-hour window on either side of Immunovet). Otherwise there are no restrictions.  Adding Omega 3 essential fatty acids in the form of fish oil, preferably from wild caught fish, will enhance this product.

Important Warnings

Using Immunovet is not a substitute for clinical oncology treatment and medications. This product should be kept strictly out of the reach of children! 


Usage is also not advised in cases of hereditary fructose intolerance or if there is hypersensitivity to wheat.

You can use Immunovet with radiation treatments or chemotherapy.  It will provide immune system support during those treatments.  You can also use Immunovet with Artemisinin; give one in the morning and the other in the evening. 

Another good combination to pair with Immunovet is called Poly MVA.  Poly MVA is a rich source of anti-oxidants and has a unique way of supporting cellular energy.  My holistic veterinarian, Dr.Dody Tyneway uses Immunovet in combination with Poly MVA and is convinced they work wonderfully in a synergistic way.  You can read about it at their website:

New Study by Dr. Dody Tyneway of Holistic Animal Hospital in Calabasas, CA

Dr. Tyneway is still conducting the studies but to date, she has treated:

4 Multicentric Malignant Lymphoma

3 Melanomas

2 Mast Cell Tumors

2 Heamngiosarcomas

1 Squamous cell carcinoma

2 Heapatic carcinomas

1 Transitional cell carcinoma

1 Lung neoplasm of unknown type

1 Eosinophyllic granuloma complex (feline)


“We feel that we have seen a favorable reponse in a majority of our patients when used as a comprehensive cancer therapy program.  Clients had reported more energy and decrease in size and slowed growth of some masses.  Immunovet has been accepted well by a majority of our patients, the exception being a cat that would not take it in the food or disguised in any way.”

She has since added 2 osteosarcoma cases and other cancers, still with encouraging results.

Immunovet’s anti-inflammatory effects make it incompatible with Neoplasene.  Use one or the other but not together.  Neoplasene uses inflammation to destroy cancer cells which is why dogs appear to be hot and will seek a cool place after receiving their daily dose of Neoplasene. 

Dosage and Usage of Immunovet powder

As an overall health supplement, sprinkle 1 gram or one teaspoon daily on food, or mix with cooked or raw food.

The metric recommendation:

  • Dogs: 1 g/10 kg body weight / day
  • Cats: 1-2 g / day / animal

Converted for Americans:


Cats - up to 5lbs 1/4 gram 1/4 teaspoonful of powder once a day sprinkled on food.
Cats - 5 and up lbs 1/2 gram 1/2 teaspoonful of powder once a day sprinkled on food.

Dogs - up to 22 lbs 1 gram 1/2 teaspoonful of powder once a day sprinkled on food.
Dogs - 22- 44 lbs 2 grams 1 teaspoonful of powder once a day sprinkled on food.
Dogs - 44- 66 lbs 3 grams 1 and 1/2 teaspoonful of powder once a day sprinkled on food.
Dogs - 66- 88 lbs 4 grams 2 teaspoonful of powder once a day sprinkled on food.
Dogs - 88 lbs and up 5 grams 2 and 1/2 teaspoonful of powder once a day sprinkled on food.



You can give twice the recommended dose for 4 weeks without adverse effects .For sick animals, you should double the dose.

You can give once daily or split the dose and give twice daily.  I recommend twice daily so there is always some circulating in the blood.

Biropharma Animal Health in Hungary introduced a new Immunovet Chewable for pets, which is ideal as a daily supplement for prevention of health problems.  One tablet per 20 pounds is the recommended dose.  In a small trial conducted with dogs suffering from cancer, they all loved the taste.

Immunovet is now available in this country on a limited basis by emailing me at  By the end of March 2013, it will be available as IMMUNITY4PETS at  I am currently working with Birophama to introduce the new chewable tablets for prevention and immune system support and the powder to assist in treating illness. 


 To remain informed on the progress of making this more available in North America, join my group:

Barbara Bouyet

© 2009 Barbara Bouyet


Last updated 08/01/2017 .
© 2004 All Rights Reserved.


Leo Links

   Start Here For Information
   An basic Understanding
   How to Use
   Memorial Sloan Kettering, NY
   How AveMar helps fight cancer
   Stand up to cancer video